Monday Night Football: Titans vs Bills Preview, Prediction & Picks

A Look at the Monday Night Football clash between the Tennessee Titans and Buffalo Bills, including our best Titans vs Bills betting picks.

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It could’ve easily been the AFC Championship Game last season.

Instead, the Tennessee Titans and Buffalo Bills matchup will have to settle for being one of the more intriguing Monday Night Football matchups of the 2022 season.

Both teams fell short on the last play in last season’s Divisional Playoffs – the Titans on a last-second Cincinnati Bengals field goal; the Bills on a Patrick Mahomes touchdown pass in overtime.

For bettors, the game figures to be one of the most wagered Monday Night matchups of the season, as two sports betting states (Tennessee and New York) go head-to-head on national television. Here’s our preview of the game, plus our Monday Night Football betting picks.

Tennessee Titans Preview and Week 1 Recap

You can’t blame the Titans’ opening 21-20 loss to the New York Giants on a ‘hangover’ from last season’s playoff disappointment. After all, the Titans were in control for much of the game.

Ryan Tannehill was efficient with 60 percent completions (20-33), 266 yards and two TD passes. Uncharacteristically, it was the running game where the Titans fell short.

Averaging only 3.6 yards per carry, the Titans were unable to seal the game up by seven points in the fourth quarter. The team ran only nine plays (compared to New York’s 25) in the fourth quarter before the Giants regained the lead with a minute to play.

Derrick Henry received only two carries for a total of two yards in the final stanza. And yet, Tannehill had Tennessee in position to win the game – but Randy Bullock hooked a 47-yard field goal as time expired.

Titans Bills Betting Picks

Clearly, the Titans need to get back to their bread-and-butter of Henry and the powerful running game carrying the team to the finish line late in games. However, encouraging signs included Tannehill’s productivity in the passing game despite the team still finding its footing in the post-AJ Brown era (traded to Philadelphia this past offseason).

Dontrell Hilliard proved an effective weapon out of the backfield, catching both touchdown passes while WR Kyle Philips led Tennessee with 66 yards receiving in his NFL debut.

Defensively, the Titans had all kinds of issues with Giants RB Saquon Barkley, whose late touchdown punctuated a 164-yard rushing day.

Buffalo Bills Preview and Week 1 Recap

The Bills are many experts’ pick to win Super Bowl 57 in February, and Buffalo’s week 1 performance did nothing to dampen the enthusiasm.

It’s one thing to beat a defending Super Bowl champion. It’s another thing entirely to do so on the road as the Bills did, going into Los Angeles and ruining the Rams’ party in a 31-10 victory that was even more dominating than the score indicates.

Buffalo gained over 400 yards of offense while holding Los Angeles to a pedestrian 243 yards. The Bills made life rough on Matthew Stafford, forcing three interceptions and sacking the Rams’ quarterback seven times.

Josh Allen Betting Odds

Josh Allen came close to a 300-yard passing night (297 to be exact), finding three different receivers on his trio of touchdown passes and adding another score rushing.

Fans came away wondering just how dominant Buffalo’s opener would have been if the Bills hadn’t committed four turnovers of their own.

Titans vs Bills Prediction

Oddsmakers started this line at Buffalo -7.5, and early action pushed it quickly to Buffalo -10… which is a little rich for our taste.

Week 2 in the NFL is Overreaction Central, as bettors and oddsmakers tend to believe everything they saw in Week One. If that’s true, the Bills are destined to dominate the AFC on the way to Super Bowl 57, and the Titans are bound to crash and burn after last season’s playoff disappointment.

In reality, however, week one could’ve been the best thing to happen to Tennessee. They saw with their own eyes they need to depend on their powerful running game late. Ball control is the best way to keep the powerful Buffalo offense at bay, and Mike Vrabel isn’t the type of coach to repeat the same mistake twice in a row.

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Meanwhile, the defensive struggles are unlikely to continue, as Buffalo is unlikely to lean on any running back the way the Giants did with Saquon Barkley (Josh Allen’s 10 carries led Buffalo week one).

Buffalo to Beat the Spread?

Everything’s pointing to Buffalo. They dominated the Super Bowl champions, they’re on extra rest, and they’re playing at home on Monday Night Football. Why wouldn’t you take the Bills?

Because it seems too easy, that’s why! Additionally, it’s the first full NFL season of live sports wagering in New York. The Bills’ hot start combined with the excitement for the home opener means plenty of Bills fans will be jumping at the chance to bet on the local favorites, potentially pushing the line even higher by Monday’s 7:15 p.m. kickoff.

Titans vs Bills Monday Night Football Betting Picks

10 points is a lot to give any team who runs the ball and avoid mistakes the way the Titans do. Add in Tennessee’s desperation to avoid an 0-2 start, and most signs point to a one-score game.

Tennessee Titans MNF betting picks

Titans vs Bills Monday Night Football Prop Bets

Ryan Tannehill (TEN) passing yards: A strong week one performance could inflate this line, but the Titans’ path to victory likely dictates a run-heavy approach. Tannehill’s under on pass yards could be a strong play as Tennessee continues to sort its depth chart at wide receiver.

Monday Night Football Betting Picks

Dawson Knox (BUF) receiving yards: Knox signed a big contract in the offseason, which may lead to some higher numbers on his props this season. But with the emergence of Gabriel Davis as the no-doubt-about-it, number-two option in the Buffalo passing game behind Stefon Diggs, Knox saw only two targets last week and caught only one pass for five yards.

Meanwhile, Tennessee shut out the Giants’ tight ends in Week 1. This doesn’t look like the best matchup for Knox.

Dawson Knox Prop Bets
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