March Madness Midwest Region Bracket Preview, Predictions & Picks 2023

Houston has star power, depth, and a coach with something to prove. But the other contenders include in-state rivals (Texas), upstarts (Xavier), and proven programs (Indiana).

FanDuel Sports

FanDuel Sports SPECIAL OFFER

Place your first bet and get 10x its value, up to $200, in Bonus Bets – win or lose!
Bet $20, Get $200 Get Bonus
Terms and conditions apply

The March Madness Midwest Region bracket features the Houston Cougars at the very top – and they might be the best potential story in this year’s Tournament.

It’s been exactly 40 years since the “Phi Slamma Jamma” Cougars lost the NCAA title game to NC State on one of the most famous plays in March Madness history.

Now they’re back with a chance to play in the Final Four just minutes from campus at Houston’s NRG Stadium. What’s more, coach Kelvin Sampson’s story of redemption is only missing a national championship.

So who can stop Houston’s date with destiny?

The March Madness Midwest Region Favorite

Houston has it all – scoring from the backcourt (American Athletic Conference Player of the Year Marcus Sasser), a projected NBA lottery pick up front (Jarace Walker) and balance (a top-10 offense AND defense.)

So why worry? Health. Sasser strained his groin in the AAC Tournament, missing the championship game and the Cougars struggled in his absence. It looks good for his return in March Madness, but the timing couldn’t be any worse.

Marcus Sasser Houston Cougars

The Midwest Region Contenders

Texas

The Longhorns have lingered all year, and they’re getting hot at the right time.

A Big 12 Conference Tournament championship was highlighted by a 20-point win over defending national champion Kansas, and the Longhorns’ collection of transfers is playing well together after a tumultuous campaign.

Foul trouble won’t bother Texas – they can go nine deep with little drop off, one of the deepest teams in the Tournament.

BetMGM Sports

BetMGM Sports FIRST BET OFFER

Use promo code ‘AMERICANBET’ for up to $1,000 paid back in Bet Credits if your first wager loses.
$1,000 First Bet Offer Get Bonus
AMERICANBET
Terms and conditions apply

Xavier

The Xavier offense led the country in assists per game this season, with guards Colby Jones and Souley Boum as the ringleaders of the efficient unit.

Five different Musketeers average double figures in scoring, challenging even the best defenses to make difficult choices on who to stop.

Indiana

Two outstanding players – forward Trayce Jackson-Davis and freshman Jalen Hood-Schifino – lead the way for the Hoosiers, whose talent is more impressive than their 22-11 record.

The Hoosiers have a victory over then-No. 1 Purdue to their credit this season, and are capable of anything when their star players are clicking.

Texas March Madness

The Midwest Region’s Cinderella Team

Kent State: The Golden Flashes won a showdown with Toledo to claim the MAC title, and the No. 13 seed get a vulnerable Indiana team right away. They can battle with anyone. Just ask Houston, who had to scratch to a 49-44 win over Kent State this season, or Gonzaga, who barely outscored the MAC champions 73-66.

Midwest Region’s Best First Round Game

No. 5 Miami (FL) vs. No. 12 Drake: Drake won’t impress you with statistics, they’ll just win – and do it convincingly. The 27-5 Bulldogs won all their games in the Missouri Valley Conference Tournament by double digits, and have wins in 13 of their last 14 contests.

Meanwhile, ACC regular-season champion Miami hopes to have big man Norchad Omier back from injury alongside ACC Player of the Year Isaiah Wong, as the Hurricanes look to get off to a hot start and repeat or surpass last year’s Elite 8 run.

DraftKings Sports

DraftKings Sports SPECIAL OFFER

Join DraftKings and bet $5+ on any pre-game moneyline. Win $150 in Bonus Bets if your bet wins!
Bet $5, Get $150 Get Bonus
Terms and conditions apply

Midwest Region Predictions

Houston’s got the best story, and pound for pound they’ve probably got the best team.

But Texas has proven their ability to go toe-to-toe with anyone, and Xavier’s versatility on offense will challenge any defense. Even one as stingy as Houston.

With Drake, Kent State, Penn State, and others, however, the story in this region may be the potential for first-round upsets. Even 14 and 15 seeds Kennesaw State and Colgate have the potential to do damage with high-scoring offenses. You won’t find a boring game in the Midwest Region.

Drake Midwest

March Madness Midwest Region Odds

Here are the odds for each team to win the Midwest Region, along with their National Championship odds (all odds from FanDuel):

TEAMTO WIN MIDWEST REGIONTO WIN NATIONAL TITLE
Houston+120+500
Texas+450+1500
Xavier+900+5500
Texas A&M+1000+4300
Indiana+1200+4800
Miami (FL)+1600+3500
Iowa State+2100+7500
Penn State+2600+19000
Iowa+2600+5500
Auburn+3700+11000
Mississippi State+6500+40000
Drake+7000+32000
Pittsburgh+9000+30000
Kent State+10000+50000
Colgate+10000+50000
Northern Kentucky+10000+50000
Kennesaw State+10000+50000
BetMGM Sports

BetMGM Sports FIRST BET OFFER

Use promo code ‘AMERICANBET’ for up to $1,000 paid back in Bet Credits if your first wager loses.
$1,000 First Bet Offer Get Bonus
AMERICANBET
Terms and conditions apply
FanDuel Sports

FanDuel Sports SPECIAL OFFER

Place your first bet and get 10x its value, up to $200, in Bonus Bets – win or lose!
Bet $20, Get $200 Get Bonus
Terms and conditions apply
DraftKings Sports

DraftKings Sports SPECIAL OFFER

Join DraftKings and bet $5+ on any pre-game moneyline. Win $150 in Bonus Bets if your bet wins!
Bet $5, Get $150 Get Bonus
Terms and conditions apply
Caesars Sports

Caesars Sports SPECIAL OFFER

Use promo code ‘EXPERTVIPFULL’ and get a first bet on Caesars up to $1,250.
$1,250 Back If You Don’t Win Get Bonus
EXPERTVIPFULL
Terms and conditions apply
PointsBet

PointsBet SECOND CHANCE

Get up to five $50 Bet Credits matching your first Fixed Odds cash bet if it loses (1 per day for 5 days).
5x Second Chance Bets Get Bonus
Terms and conditions apply

Latest Offers

Latest News

2023 Masters Preview: Favorites, Contenders & Sleeper Picks

Our best 2023 Masters bets for the first major of the PGA Tour season, from the favorites to the top sleeper picks.

Best MLB Closers 2023: The MLB’s Bullpen Aces for 2023 Fantasy

The best closers in baseball all have one thing in common, opportunity. We look at the best options for your MLB Fantasy in 2023, plus some history of the game’s greatest.

The 7 Best March Madness Betting Promos 2023: Get $2,000+ in Bonuses

The best March Madness betting promos for you to take advantage of when placing your college basketball wagers in March.

Who Has the Best Online Casino Welcome Bonus?

Which online casino has the biggest welcome bonus? It's the question that everyone wants to know, and we have some insight.

How to Play BetRivers Basketball Squares Game for NBA & NCAA

BetRivers Basketball Squares adds entertainment value and more ways to win on game day. Here's how you can play today.

More Articles Like This