The March Madness East region of the bracket features Big Ten champion Purdue, the 1 seed who no one seems to believe in, plus blue bloods Duke and Kentucky.
When the East Region of the March Madness bracket tips off on Thursday, no team will have more bulletin-board material than Purdue.
Theyβre the 1 seed, the Big Ten champions, and they have the likely Player of the Year β but itβs hard to find an expert whoβs taking the Boilermakers to make the Final Four.
Can one great player carry a team in March Madness?


The March Madness East Region Favorite
Purdue. Are you really the favorite if no one believes in you?
Hereβs what Purdue has going for them β they rose above a mediocre pack to dominate the Big Ten in the regular season and conference tournament.
They accomplished this largely on the considerable shoulders of Zack Edey, the Naismith Award frontrunner averaging 22.3 points and 12.9 rebounds per game. At 7-foot-4 and 305 lbs., Edey represents the single most challenging player matchup in March Madness.
The concerns seem to focus on his supporting cast β only one other Boilermaker averages double-figure scoring, guard Fletcher Loyer with 10.9 per game β and how Purdue will survive if an opponent can contain Edey.


The East Region Contenders
Marquette
Hereβs one popular pick to outlast Purdue β the Big East champion Golden Eagles, led by four double-digit scorers and a threat to present matchup problems specifically tailored to beat Purdue.
Marquetteβs Tyler Kolek is second in the country in assists per game (7.7) and the team ranks second in fastbreak points, presenting an interesting contrast to methodical Purdue.
Duke
Coach K is retired, but you canβt have a March Madness discussion without the Blue Devils, flying high off an ACC Tournament title and playing their best basketball of the year.
Beset by injuries early, Duke is 17-1 with their full lineup available as it should be at the start of March Madness.
Kentucky
Another blue blood featuring the defending Player of the Year in Oscar Tshiebwe, the Wildcats are menaces on the offensive boards. They rebound almost 40 percent of their own misses, and the talent is second to none.
Consistency is the issue for a team that just last year saw its high hopes unravel as a 2 seed in an opening loss to St. Peterβs.
FanDuel Sports SPECIAL OFFER
The East Regionβs Cinderella Team
Louisiana
Tough call in a loaded region featuring Michigan State, Oral Roberts, and others. But the Raginβ Cajuns are more than just a cool nickname with the interior duo of Jordan Brown and Terence Lewis.
With point guard Zakai Ziegler lost to injury, No. 4 Tennessee figures to have its hands full against a Louisiana team in search of the programβs first March Madness win since 1992.


East Regionβs Best First-Round Game
No. 8 Memphis vs. No. 9 Florida Atlantic: The No. 8 Tigers come in off a win against no less than the Midwestβs top seed in Houston.
The Tigers play fast, they play aggressive, and theyβre big with plenty of depth. Theyβre one of the teams that causes matchup problems and nightmares for power programs in March every year.
Meanwhile, Florida Atlantic is the other type of team that poses problems β experienced, confident, and prolific. The metrics and analytics love the Owls, champions of Conference USA tied for the most wins in the country with 31. They lead the nation in bench points and wonβt be intimidated by Memphisβ depth.
BetRivers Sports SECOND CHANCE
East Region Predictions
If March Madness was predictable, it wouldnβt be as popular.
So donβt write off Purdue just because so many experts do. Edey is a unique weapon, and teams will struggle to prepare for him on such short notice.
At the same time, a region with Duke, Kentucky, and Michigan State has plenty of options β and theyβre not even among the top-4 seeds. The East is this yearβs wide-open region, with 6-7 teams having a convincing case to make the Final Four.


March Madness East Region Pick


March Madness East Region Odds
Here are the odds for each team to win the East Region, along with their National Championship odds (all odds from FanDuel):
TEAM | TO WIN EAST REGION | TO WIN NATIONAL TITLE |
Purdue | +320 | +1200 |
Marquette | +370 | +1500 |
Tennessee | +600 | +2500 |
Duke | +750 | +3000 |
Kentucky | +850 | +3500 |
Kansas State | +1100 | +7500 |
Michigan State | +1200 | +6000 |
Memphis | +1800 | +10000 |
Florida Atlantic | +2500 | +13000 |
Providence | +2500 | +13000 |
USC | +2500 | +15000 |
Oral Roberts | +10000 | +50000 |
Louisiana | +13000 | +50000 |
Texas Southern | +25000 | +50000 |
Montana State | +25000 | +50000 |
Vermont | +25000 | +50000 |
Fairleigh Dickinson | +25000 | +50000 |